Why Not a 1 to 1 Thyroid Ratio?

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In thyroid supplements, the ratio of T3 to T4 can vary depending on the specific supplement and the individual’s needs. T4, or thyroxine, is a prohormone that is converted into T3, or triiodothyronine, the active form of thyroid hormone in the body. T3 is responsible for regulating metabolism and plays a crucial role in maintaining optimal energy levels, body temperature, and mood.

A higher ratio of T3 to T4 in a thyroid supplement can have different effects depending on the individual. Some people may benefit from a higher ratio of T3 to T4, especially if they have a conversion issue where their body struggles to convert T4 into T3. However, others may experience negative side effects such as heart palpitations, anxiety, or insomnia when taking high doses of T3.

It is important to note that thyroid supplements should only be taken under the guidance of a healthcare professional who can monitor thyroid function and adjust the dosage as necessary. Additionally, other factors such as lifestyle, stress levels, and nutrient deficiencies can also impact thyroid health and should be addressed as part of a comprehensive treatment plan.

In one of my e-mail exchanges with Dr. Peat, I attempted to obtain information regarding the presence of a lab value that would indicate too much T3 as a supplement. Dr. Peat replied in the negative, which makes me ascertain that his only reason for suggesting T4 was that outlined in one of his articles, specifically that taking too much T3, in the absence of T4, can cause reactivity in the patient, as well as possible heart palpitations. In his case his heart kept skipping beats.

With regards to a 1:1 T3 to T4 ratio you’ve mentioned for those with impaired livers, do you know of any lab values that would indicate too much T3 in their thyroid ratio and would suggest an increase in T4?

— Dave Foster on Wed, Feb 7, 2018, 6:46 PM

No, that can happen when stress increases reverse T3.

— Ray Peat on Wed, Feb 7, 2018, 8:31 PM

Okay, so I suppose it’s only reliant upon negative symptoms such as arrhythmias (such as when you took only T3).

— Dave Foster on Wed. Feb 7, 2018, 9:35 PM







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